Adair Margo Gallery opened its doors to the public on December 5, 1985 in Wakefield Plaza, a turn-of-the-century building north of downtown El Paso. In two spacious galleries, it exhibited over 200 contemporary artists from the United States and a dozen foreign countries. It also exhibited historic artists from the Southwest, including Tom Lea, José Cisneros, and Manuel Acosta.
The Gallery placed works of regional artists in public collections including the Metropolitan Museum of Art, Smithsonian American Art Museum, National Museum of Women in the Arts, Dallas Museum of Art, the Oval Office of the White House, and U.S. Embassies worldwide.
In 2010, Adair Margo closed her gallery to establish the Tom Lea Institute. She continues to consult privately.